Name: Na Jiao

姓名：焦娜

Education: PhD

学历：博士

Advisor Status: Doctoral Supervisor

导师情况：博士生导师

Research areas：Bioinformatics

研究领域：生物信息学

Research focus：Microbiota-Host Interaction; Microbiome Exploration and Mining; Development of Metagenomic Analysis Techniques and Platforms

研究方向：微生物与宿主互作、微生物资源挖掘、微生物组学分析方法及平台开发

Current position：Fudan University

当前单位：复旦大学

Personal Profile: Na Jiao, PI of Microbiome Systems Biology Research Group, Department of Microbiology and Immunology, Microbiome Center, School of Life Sciences, Fudan University, Doctoral Supervisor. She graduated from Jilin University in 2014 with a Bachelor Degree in Food Science and Engineering and earned a Ph.D. in Biology (Bioinformatics) from Tongji University in 2019. She conducted postdoctoral research at the Sixth Affiliated Hospital of Sun Yat-sen University from 2019 to 2021. From 2021 to 2023, she served as a distinguished researcher (PI) at the National Clinical Research Center for Child Health and Diseases, Children's Hospital, Zhejiang University School of Medicine. In January 2024, she joined the Department of Microbiology and Immunology, Microbiome Center at Fudan University as young research fellow (PI). Her research focuses on interactions between microbiota and hosts, exploration and mining of microbiome, and advancement and development of metagenomic analysis techniques and platforms. In recent years, she has published numerous research papers in prestigious journals such as Nature Microbiology, Nature Protocols, Nature Communications, Cell Reports Medicine and Gut, primarily revolving around the prevention and treatment of chronic diseases through microbiome and host-microbiota interactions. She has been recognized in the Postdoctoral Innovative Talent Support Program and has received funding from the National Natural Science Foundation of China's Young Scientists Fund.

More about me: https://life.fudan.edu.cn/0f/e9/c31282a659433/page.htm

个人简介：焦娜博士现任复旦大学生命科学学院微生物学与免疫学系、微生物组中心青年研究员（课题组长），博士生导师。2014年毕业于吉林大学，获得食品科学与工程学士学位。2019年毕业于同济大学，获得生物学博士学位（生物信息学方向）。2019-2021年在中山大学附属第六医院从事博士后研究。2021-2023年在浙江大学医学院附属儿童医院国家儿童健康与疾病临床医学研究中心任特聘研究员（课题组长）。2024年1月至今在复旦大学生命科学学院微生物学与免疫学系、微生物组中心从事科研和教学工作。焦娜博士领导的微生物组系统生物学课题组研究方向聚焦于微生物与宿主互作、微生物资源挖掘和微生物组学分析方法及平台开发。近年来围绕微生物与慢病防治、微生物-宿主互作，以第一或通讯作者身份(含并列)在Nature Microbiology、 Nature Protocols、 Nature Communications、Cell Reports Medicine和Gut 等期刊上发表了多篇研究论文。入选博士后创新人才支持计划和获得国家自然科学基金青年科学基金项目资助。

更多信息：https://life.fudan.edu.cn/0f/e9/c31282a659433/page.htm

Work Experience 工作经历

· Jan. 2024- Present: Young Research Fellow (Principal Investigator), Doctoral Supervisor, Microbiome Center, Fudan University

· 2024年1月——至今：复旦大学微生物组中心 青年研究员（课题组长）、博士生导师

· Jan. 2024- Present: Young research fellow (Principal Investigator), Doctoral Supervisor, Department of Microbiology and Immunology, School of Life Sciences, Fudan University

2024年1月——至今：复旦大学生命科学学院微生物学与免疫学系 青年研究员（课题组长）、博士生导师

· Sep. 2021-Dec. 2023: Distinguished research fellow (Principal Investigator), National Clinical Research Center for Child Health, Children's Hospital of Zhejiang University School of Medicine

2021年9月——2023年12月：浙江大学附属儿童医院国家中心 特聘研究员（课题组长）

· Jul. 2019-Aug. 2021: Postdoctoral fellow, Bioinformatics, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

2019年7月——2021年8月：中山大学附属第六医院 生物信息学 博士后

Education 教育背景

· Sep. 2014-Jun. 2019, Ph.D. in Biology (Bioinformatics), School of Life Sciences and Technology, Tongji University, Shanghai, China

2014年9月-2019年6月：同济大学 生命科学与技术学院 生物学博士学位(生物信息学方向)

· Sep. 2010-Jun. 2014, Bachelor’s Degree in Food Science and Engineering, College of Biological and Agricultural Engineering, Jilin University, Jilin, China

2010年9月-2014年6月：吉林大学 生物与农业工程学院 食品科学与工程学士学位

Research Project 科研项目

1. National Natural Science Foundation of China, Young Scientists Fund, 82000536, Mechanism for the gut microbiota-mediated bile acid metabolism promoting NAFLD pathogenesis via gut-liver axis, 2021-01 to 2023-12, 240000, in research，PI

国家自然科学基金委员会, 青年科学基金项目，82000536，肠道菌群介导的胆汁酸代谢通过肠肝轴诱导NAFLD的病理机制探究，2021-01至2023-12，24万，在研，主持

2. Higher Education Institutions Fundamental Research Project, Young Teachers Training Programs, 20ykpy07, Altered gut microbiome and mechanism in FUT2 loss-of-function mutants in inflammatory bowel disease, 2020-01to 2021-01, 120000, conclusion，PI

高校基本科研业务费，青年教师培育项目，20ykpy07，FUT基因突变型炎症性肠病中肠道菌群的改变及其介导的病理机制研究，2020-01至2021-01，12万，结题，主持

3. China Postdoctoral Science Foundation, General Program, 2019M663252, Role of the choline metabolizing microbiota in the pathogenesis of non-alcoholic fatty liver disease, 2020-01to 2021-08，80000, conclusion，PI

博士后科学基金，面上资助，2019M663252，肠道菌群胆碱代谢在NAFLD发病机制中的作用研究，2020-01至2021-08，8万元，结题，主持

4. China Postdoctoral Science Foundation, Postdoctoral Innovative Talent Support Program, BX20190393, Identification of bile acid metabolizing bacteria and individualized intervention in the pathogenesis of nonalcoholic fatty liver disease, 2019-09 to 2021-08, 600000, conclusion，PI

博士后科学基金，博士后创新人才支持计划，BX20190393，非酒精性脂肪肝病发病机制中胆酸代谢菌种确定及个性化干预研究，2019-09至2021-08，60万元，结题，主持

Publications: Authored 30 SCI papers (18 as first/corresponding author, with 3 in ESI)

同行评议论文: 发表SCI论文30篇（其中18为第一/通讯作者，3篇ESI）

Selected Publications：

1. Wenxing Gao^#, Weili Lin^#, Qiang Li^#, Wanning Chen, Wenjing Yin, Xinyue Zhu, Sheng Gao, Lei Liu, Wenjie Li, Dingfeng Wu, Guoqing Zhang^*, Ruixin Zhu^*, Na Jiao^*. (2024). Identification and validation of microbial biomarkers from cross-cohort datasets using xMarkerFinder, Nature Protocols, https://doi.org/10.1038/s41596-024-00999-9.

2. Na Jiao^*, Lixin Zhu^*, Ruixin Zhu^*. (2024). The search for authentic microbiome–disease relationships. Nature Medicine. https://doi.org/10.1038/s41591-024-02920-z

3. Xinyue Zhu^#, Pingping Xu^#, Ruixin Zhu*, Wenxing Gao, Wenjing Yin, Ping Lan, Lixin Zhu*, Na Jiao*[最后通讯], Multi-kingdom microbial signatures in excess body weight colorectal cancer based on global metagenomic analysis, Communications Biology, 2024, 7(24), 10.1038/s42003-023-05714-0

4. Wenxing Gao^#, Xiang Gao^#, Lixin Zhu*, Sheng Gao, Ruicong Sun, Zhongsheng Feng, Dingfeng Wu, Zhanju Liu*, Ruixin Zhu*, Na Jiao* [最后通讯] , Multimodal metagenomic analysis reveals microbial single nucleotide variants as superior biomarkers for early detection of colorectal cancer. Gut Microbes, 2023, 15(2):2245562.

5. Xiang Gao^#, Ruicong Sun^#, Na Jiao^#, Xiao Liang, Gengfeng Li, Han Gao, Xiaohan Wu, Muqing Yang, Chunqiu Chen, Liang Chen, Wei Wu, Zhong Li, Yingzi Cong, Ruixin Zhu*, Tiannan Guo*, Zhanju Liu*, Integrative multi-omics deciphers the spatial characteristics of host-gut microbiota interactions in Crohn’s disease. Cell Reports Medicine. 2023, 20;4(6):101083.

6. Dingfeng Wu^#, Lei Liu^#, Na Jiao^#, Yida Zhang, Li Yang, Chuan Tian, Ping Lan, Lixin Zhu*, Rohit Loomba*, and Ruixin Zhu*. Targeting Keystone Species Helps Restore the Dysbiosis of Butyrate‐Producing Bacteria in Nonalcoholic Fatty Liver Disease. iMeta. 2022,1(4): e61

7. Ningning Liu^#, Na Jiao^#, Jing-Cong Tan^#, Ziliang Wang^#, Dingfeng Wu, An-Jun Wang, Jie Chen, Liwen Tao, Chenfen Zhou, Wenjie Fang, Io Hong Cheong, Weihua Pan, Wanqing Liao, Zisis Kozlakidis, Christopher Heeschen, Geromy G. Moore, Lixin Zhu*, Xingdong Chen*, Guoqing Zhang*, Ruixin Zhu*, Hui Wang*.  Multi-kingdom microbiota analyses identify bacterial-fungal interactions and biomarkers of colorectal cancer across cohorts. Nature Microbiology, 2022,7(2):238-250. ESI high cited

8. Yuqi Wu^#, Na Jiao^#, Ruixin Zhu*, Yida Zhang, Dingfeng Wu, An-Jun Wang, Sa Fang, Liwen Tao, Yichen Li, Sijing Cheng, Ping Lan, Chuan Tian*, Ning-Ning Liu*, Lixin Zhu*. Identification of microbial markers across populations in early detection of colorectal cancer. Nature Communication, 2021,12(1):3063. ESI high cited

9. Na Jiao^#, Rohit Loomba#*, Zi-Huan Yang, Dingfeng Wu, Sa Fang, Richele Bettencourt, Ping Lan, Ruixin Zhu*, Lixin Zhu*. (2021). Alterations in bile acid metabolizing gut microbiota and specific bile acid genes as a precision medicine to subclassify NAFLD. Physiological Genomics. 53(8):336-348.

10. Na Jiao, Susan S Baker*, Adrian Chapa-Rodriguez, Wensheng Liu, Colleen A Nugent, Maria Tsompana, Lucy Mastrandrea, Michael J Buck, Robert D Baker, Robert J Genco, Ruixin Zhu*, Lixin Zhu*. Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD. Gut, 2018,67(10):1881-1891. ESI high cited

11. Na Jiao, Susan S. Baker, Colleen A. Nugent, Maria Tsompana, Liting Cai, Yong Wang, Michael J. Buck, Robert J. Genco, Robert D. Baker, Ruixin Zhu*, Lixin Zhu*. Gut microbiome may contribute to insulin resistance and systemic inflammation in obese rodents: a meta-analysis. Physiological Genomics, 2018,50(4):244-254. (APS selected Award)